Prior to joining TGen, John C. Carpten was an intramural tenure track investigator with the Cancer Genetics Branch of the National Human Genome Research Institute (NHGRI). While a fellow and later a tenure track investigator at NHGRI/NIH, he co-led the first published genome-wide scan for prostate cancer susceptibility genes published in 1996 in Science. Dr. Carpten also has an intense focus on understanding the role of biology in disparate cancer incidence and mortality rates seen among minority populations. Through his leadership, the African American Hereditary Prostate Cancer (AAHPC) Study was conceived. A model for genetic linkage studies in underrepresented populations, this study led to the first genome-wide scan for prostate cancer susceptibility genes in African Americans. He has recently co-authored a series articles describing the roles of genetic variants in prostate cancer risk in Genome Research, Journal of the National Cancer Institute, and the New England Journal of Medicine.
Dr. Carpten’s laboratory participated in a study that implicated common NFkB pathway mutations in Multiple Myeloma,. He and his team, in collaboration with the Broad Institute of Harvard and MIT, have profiled the genomes and transcriptomes of 250 myeloma tumors. This is among the largest cancer genome studies ever performed.
More recently, Dr. Carpten has begun to apply Next Generation Sequencing (NGS) technologies for deep genomic profiling of tumors. These technologies offer the opportunity to sequence entire cancer genomes to discover mutations, copy number changes, and rearrangements such as translocations. This work has led to the discovery of genomic alterations in lethal prostate tumors. His research at TGen is using cutting edge molecular techniques and computational analysis of Human Genome Sequence data in search of genes predisposing men to hereditary prostate cancer.
In 2014, the American Association for Cancer Research (AACR) honored Dr.. Carpten with the 2014 Distinguished Lectureship on the Science of Health Disparities, funded by Susan G. Komen.
Dr. Carpten received his Ph.D. from the Department of Molecular Genetics, The Ohio State University in 1994.
Genetics and Genome Scineces in Cancer Health Disparities
Friday, November 3
12:45 - 1:45 pm